Sugar acids and derivatives
Medchemexpress LLC Achyranthoside D | 168009-91-4 | 25 MG
Achyranthoside D is a triterpene saponin isolated from the root of Achyranthes. It has a molecular formula of C53H82O25 and a molecular weight of 1119.20. This product is typically supplied as a white to off-white solid with a purity of 98.74%.
- A triterpene saponin from Achyranthes root
- White to off-white solid appearance
- Purity of 98.74%
- Molecular formula: C53H82O25
- Molecular weight: 1119.20
- Recommended storage at 4°C, protected from light
- In solvent, stable for 6 months at -80°C or 1 month at -20°C, protected from light
Medchemexpress LLC [D-Pro2] Spantide I TFA | 99.2% | 10 MG
[D-Pro2] Spantide I TFA is a Spantide analog that acts as a selective NK1 receptor antagonist. This product is intended for research use only.
- Selective NK1 receptor antagonist
- Shipped at room temperature (continental US, may vary elsewhere)
- Store as powder at -80°C for 2 years or -20°C for 1 year
- Store in solvent at -80°C for 6 months or -20°C for 1 month
- Recommended for research use only
Medchemexpress LLC Prosaikogenin D | 103629-72-7 | 10 MG
Prosaikogenin D is isolated from the roots of Buleurum bicaule Helm (Apiaceae) and exhibits anti-cancer activity.
- Suppresses the proliferation of A549 cells with an IC50 of 57.2 μg/mL.
Medchemexpress LLC Sodium zirconium cyclosilicate | 17141-74-1 | 95.0% | 50 MG
Sodium zirconium cyclosilicate is an inorganic, microporous zirconium silicate cation exchanger used in research to selectively remove excess potassium (K+) in vivo. It is supplied for preclinical and biochemical studies, including hyperkalemia and chronic kidney disease research, and is provided at laboratory-grade purity.
- Selective potassium binding for ion-exchange studies.
- Non-absorbed inorganic sorbent suitable for in vivo models.
- Supplied at 95.0% purity for consistent results.
- Available in small research pack sizes from 5 mg to 500 mg.
- Useful for biochemical assays and renal disease research.
Medchemexpress LLC Heparin sodium salt | 9041-08-1 | 50 MG
Heparin sodium salt (Sodium heparin) is an anticoagulant that reversibly binds to antithrombin III (ATIII), significantly accelerating its inactivation of coagulation enzymes such as thrombin factor IIa and factor Xa. It also notably inhibits exosome-cell interactions. This potent anticoagulant is a complex linear polymer, stabilizing FGF-FR binding and promoting FGFR dimerization.
- Anticoagulant
- Binds reversibly to antithrombin III (ATIII)
- Accelerates ATIII's inactivation of thrombin factor IIa and factor Xa
- Inhibits exosome-cell interactions
- Stabilizes FGF-FR binding and promotes FGFR dimerization
Medchemexpress LLC Arnicolide D | 34532-68-8 | 10 MG
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. It demonstrates cytotoxicity against tumor cells, inducing cell cycle arrest, apoptosis, and oncosis. Arnicolide D exhibits anti-tumor activity.
- Antitumor agent: Is cytotoxic to tumor cells and has anti-tumor activity.
- Induces cell cycle arrest and apoptosis in nasopharyngeal carcinoma cells by activating the caspase signaling pathway and inhibiting the PI3K/AKT/mTOR and STAT3 signaling pathways.
- Induces endoplasmic reticulum stress-mediated and ROS-dependent oncosis in hepatocellular carcinoma cells via ATF4 and CHOP.
- Demonstrates anti-melanoma effects and inhibits the NF-κB pathway in an in vivo B16F10 allograft mouse model.
- High purity of 99.69%.
- Solid, white to off-white appearance.
Medchemexpress LLC D-α-Hydroxyglutaric acid | 13095-47-1 | 98.0% | 148.11 | 25 MG
D-α-Hydroxyglutaric acid | 13095-47-1 | 98.0% | 148.11 | 25 MG
AdipoGen C9-DL-HSL
Chemical. CAS 106983-32-8. Formula C13H23NO3. MW 241.3. N-Nonanoyl-DL-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression and affecting cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms.
Medchemexpress LLC 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside | 37067-30-4 | 99.95% | 379.36 | 1 ML
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase. The enzyme functionality is assessed by its ability to remove terminal β-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues from this compound. This product is supplied as a 10 mM solution in 1 mL of DMSO, ready for reconstitution. For optimal stability, the solution should be stored at 4°C, protected from light. Once in solvent, store at -80°C for up to 6 months or -20°C for 1 month, also protected from light.
- Fluorogenic substrate for N-acetyl-β-D-glucosaminidase
- Assesses enzyme functionality by removing terminal β-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues
- Can be prepared in DMSO at 50 mg/mL (131.80 mM)
- Requires ultrasonication for preparation
- Newly opened DMSO is recommended due to hygroscopic nature affecting solubility
Medchemexpress LLC β-D-glucopyranosiduronic acid p-nitrophenyl carbonate derivative | 894095-98-8 | 99.6% | 913.83 g/mol | C45H43N3O18 | 1 G
β-D-glucuronide-pNP-carbonate is a glucuronide-cleavable carbonate linker used to attach payloads to antibodies for research-scale antibody-drug conjugate (ADC) synthesis. It is supplied as a purified small-molecule reagent for linker-payload assembly and analytical characterization.
- Cleavable glucuronide-based linker responsive to glycosidase cleavage.
- Reported purity around 99.6%.
- Molecular formula C45H43N3O18; molecular weight 913.83 g/mol.
- Available in small-scale packaging including 1 G; larger quantities available on request.
- Supporting documents include datasheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Mac glucuronide linker-1 | 2222981-71-5 | MFCD32671554 | 96.4% | 897.90 | C42H47N3O17S | 50 MG
MAC glucuronide linker-1 is a cleavable glucuronide-based linker designed for antibody-drug conjugate (ADC) research. It enables enzymatic release of payloads from antibody-payload conjugates, facilitating controlled drug release in ADC development.
- Cleavable glucuronide linker for ADCs.
- Designed for enzymatic payload release by glucuronidase.
- Suitable for antibody-agent conjugations and linker-payload development.
- Reported purity approximately 96.4% and molecular weight 897.90.
- Available in multiple pack sizes, including 50 MG.
Medchemexpress LLC Beta-Cortol | 667-65-2 | 99.9% | 368.51 | 10 MG
Beta-Cortol is an O-glycosylated compound and a cortisol metabolite that can be isolated from the leaves of the mulberry cultivar Yu 711. Its concentration significantly decreases when the plant is subjected to drought stress. Beta-Cortol acts as a biomarker, with serum levels in early non-small cell lung cancer models showing a downregulation to 1/8 of the preoperative level after tumor resection. Due to these significant changes under specific pathological conditions, Beta-Cortol is extensively used in studies related to early non-small cell lung cancer.
- O-glycosylated compound and cortisol metabolite.
- Isolated from the leaves of mulberry cultivar Yu 711.
- Concentration decreases significantly under drought stress in plants.
- Serves as a biomarker for early non-small cell lung cancer.
- Serum levels are significantly downregulated in non-small cell lung cancer models after tumor resection.
Medchemexpress LLC SN-38 glucuronide | 121080-63-5 | 99.5% | 568.53 | 1 MG
SN-38 glucuronide, also known as SN-38G, is an inactive metabolite of the anticancer molecule Irinotecan. It has known toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor used in research for colon and rectal cancer. SN-38 glucuronide can be reactivated by gut microbial β-glucuronidase enzymes, which remove the glucuronic acid moiety, thus increasing its toxic effects on the intestine.
- Inactive metabolite of Irinotecan.
- Has toxic effects on the gastrointestinal tract.
- Can be reactivated by gut microbial β-glucuronidase enzymes.
- Relevant in the study of colon and rectal cancer.
- Cells metabolizing SN38 to SN38-G show increased resistance to extracellular SN38.
Medchemexpress LLC Homo-PROTAC pVHL30 degrader 1 | 2244684-49-7 | 99.4% | 1179.45 | 25 MG
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC, consisting of two ligands of von Hippel-Lindau. It dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid, and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response. This product is for research use only.
- Dimerizes von Hippel-Lindau (VHL) with high avidity in vitro.
- Induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines.
- Acts in a highly isoform-selective fashion.
- Does not trigger a hypoxic response.
Medchemexpress LLC Intestinal Alkaline Phosphatase Antibody (YA1559) | 10 UL
The Intestinal Alkaline Phosphatase Antibody (YA1559) is a rabbit-derived, non-conjugated IgG monoclonal antibody designed to target Intestinal Alkaline Phosphatase. This enzyme is a key component of the gut mucosal defense system, functioning in the detoxification of lipopolysaccharide and preventing bacterial translocation within the gut. It can hydrolyze various phosphate compounds and is localized to the cell membrane as a homodimer.
- Derived from rabbit
- Monoclonal and recombinant
- Non-conjugated
- Reacts with human samples
- Formulated in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- Liquid appearance
- Immunogen derived from human intestinal alkaline phosphatase
- Ships with blue ice